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Article

Endothelial nitric oxide synthase (NOS3) knockout decreases NOS2 induction, limiting hyperoxygenation and conferring protection in the postischemic heart.

American journal of physiology. Heart and circulatory physiology - 1 Mar 2007

Zhao Xue, Chen Yeong-Renn, He Guanglong, Zhang Aiwen, Druhan Lawrence J, Strauch Arthur R, Zweier Jay L

Abstract excerpt

Although it has been shown that endothelial nitric oxide synthase (eNOS)-derived nitric oxide downregulates mitochondrial oxygen consumption during early reperfusion, its effects on inducible NOS (iNOS) induction and myocardial injury during late reperfusion are unknown. Wild-type (WT) and eNOS(-/-) mice were subjected to 30 min of coronary ligation followed by reperfusion. Expression of iNOS mRNA and protein...

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Source

Identifiers

PMID: 17114245
DOI: 10.1152/ajpheart.00264.2006

Genes

NOS2
NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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