Article
Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy.
Circulation - 17 Jul 2001
Patel R, Nagueh S F, Tsybouleva N, Abdellatif M, Lutucuta S, Kopelen H A, Quinones M A, Zoghbi W A, Entman M L, Roberts R, Marian A J
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy is a genetic disease characterized by cardiac hypertrophy, myocyte disarray, interstitial fibrosis, and left ventricular (LV) dysfunction. We have proposed that hypertrophy and fibrosis, the major determinants of mortality and morbidity, are potentially rev...
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