Article
Analysis of SOX10 function in neural crest-derived melanocyte development: SOX10-dependent transcriptional control of dopachrome tautomerase.
Developmental biology - 15 Sept 2001
Potterf S B, Mollaaghababa R, Hou L, Southard-Smith E M, Hornyak T J, Arnheiter H, Pavan W J
Abstract excerpt
SOX10 is a high-mobility-group transcription factor that plays a critical role in the development of neural crest-derived melanocytes. At E11.5, mouse embryos homozygous for the Sox10(Dom) mutation entirely lack neural crest-derived cells expressing the lineage marker KIT, MITF, or DCT. Moreover, neural crest cell cultures derived from homozygous embryos do not give rise to pigmented cells. In contrast, in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.