Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The importance of having your SOX on: role of SOX10 in the development of neural crest-derived melanocytes and glia.

Oncogene - 19 May 2003

Mollaaghababa Ramin, Pavan William J

Abstract excerpt

SOX10 is a member of the high-mobility group-domain SOX family of transcription factors, which are ubiquitously found in the animal kingdom. Disruption of neural crest development in the Dominant megacolon (Dom) mice is associated with a Sox10 mutation. Mutations in human Sox10 gene have also been linked with the occurrence of neurocristopathies in the Waardenburg-Shah syndrome type IV (WS-IV), for which the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Developmental
Share to High Mobility Group Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanocytes

Share to Neural Crest

Share to Neuroglia

Share to Sequence Homology, Amino Acid

Share to SOXE Transcription Factors

Share to Waardenburg Syndrome

Source

Identifiers

PMID: 12789277
DOI: 10.1038/sj.onc.1206442

Genes

SOX10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The importance of having your SOX on: role of SOX10 in the development of neural crest-derived melanocytes and glia.PMID 12789277Read ↗

The role of SOX10 during enteric nervous system development.Semantic proximity Read ↗

SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.Semantic proximity Read ↗

Myelin deficiencies in both the central and the peripheral nervous systems associated with a SOX10 mutation.Semantic proximity Read ↗

Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling.Semantic proximity Read ↗

Loss-of-function mutations in SOX10 cause Kallmann syndrome with deafness.Semantic proximity Read ↗

[Kallmann syndrome with deafness caused by SOX10 mutation: Advances in research].Semantic proximity Read ↗

A novel frameshift mutation in SOX10 causes Waardenburg syndrome with peripheral demyelinating neuropathy, visual impairment and the absence of Hirschsprung disease.Semantic proximity Read ↗

Clinical Significance of SOX10 Expression in Human PathologySemantic proximity Read ↗

Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.Semantic proximity Read ↗

Neurological phenotype in Waardenburg syndrome type 4 correlates with novel SOX10 truncating mutations and expression in developing brain.Semantic proximity Read ↗

Analysis of SOX10 function in neural crest-derived melanocyte development: SOX10-dependent transcriptional control of dopachrome tautomerase.Semantic proximity Read ↗

A direct role for Sox10 in specification of neural crest-derived sensory neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.