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The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10

24 May 2011

Abstract excerpt

Waardenburg syndromes are characterized by pigmentation and autosensory hearing defects, and mutations in genes encoding transcription factors that control neural crest specification and differentiation are often associated with Waardenburg and related disorders. For example, mutations in SOX10 result in a severe form of Waardenburg syndrome, Type IV, also known as Waardenburg-Hirschsprung disease, characterized...

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PMID: 21610032
DOI: 10.1242/dev.056804

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