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Article

Transcriptional regulation of mitfa accounts for the sox10 requirement in zebrafish melanophore development.

Development (Cambridge, England) - 1 Jun 2003

Elworthy Stone, Lister James A, Carney Tom J, Raible David W, Kelsh Robert N

Abstract excerpt

The transcription factor Sox10 is required for the specification, migration and survival of all nonectomesenchymal neural crest derivatives including melanophores. sox10(-/-) zebrafish lack expression of the transcription factor mitfa, which itself is required for melanophore development. We demonstrate that the zebrafish mitfa promoter has sox10 binding sites necessary for activity in vitro, consistent with...

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Share to Crosses, Genetic
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High Mobility Group Proteins

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Share to Microphthalmia-Associated Transcription Factor

Share to SOXE Transcription Factors

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Source

Identifiers

PMID: 12736222
DOI: 10.1242/dev.00461

Genes

MITF
SOX10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transcriptional regulation of mitfa accounts for the sox10 requirement in zebrafish melanophore development.PMID 12736222Read ↗

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