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Article

Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage.

Mechanisms of development - 1 Feb 2006

Hakami Ramin Mollaaghababa, Hou Ling, Baxter Laura L, Loftus Stacie K, Southard-Smith E Michelle, Incao Arturo, Cheng Jun, Pavan William J

Abstract excerpt

Mutations in the transcription factor Sox10 or Endothelin Receptor B (Ednrb) result in Waardenburg Syndrome Type IV (WS-IV), which presents with deficiencies of neural crest derived melanocytes (hypopigmentation) and enteric ganglia (hypoganglionosis). As Sox10 and Ednrb are expressed in mouse migratory neural crest cells and melanoblasts, we investigated the possibility that SOX10 and EDNRB function through a...

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Source

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Identifiers

PMID: 16412618
DOI: 10.1016/j.mod.2005.11.004
PMCID: PMC1373669

Genes

SOX10
EDNRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage.PMID 16412618Read ↗

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The importance of having your SOX on: role of SOX10 in the development of neural crest-derived melanocytes and glia.Semantic proximity Read ↗

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Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model.Semantic proximity Read ↗

Cell-autonomous and cell non-autonomous signaling through endothelin receptor B during melanocyte development.Semantic proximity Read ↗

Myelin deficiencies in both the central and the peripheral nervous systems associated with a SOX10 mutation.Semantic proximity Read ↗

Neurological phenotype in Waardenburg syndrome type 4 correlates with novel SOX10 truncating mutations and expression in developing brain.Semantic proximity Read ↗

The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10Semantic proximity Read ↗

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Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndromeSemantic proximity Read ↗

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