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Article

Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor.

Development (Cambridge, England) - 1 Jun 1997

Opdecamp K, Nakayama A, Nguyen M T, Hodgkinson C A, Pavan W J, Arnheiter H

Abstract excerpt

The more than 20 different Mitf mutations in the mouse are all associated with deficiencies in neural crest-derived melanocytes that range from minor functional disturbances with some alleles to complete absence of mature melanocytes with others. In the trunk region of wild-type embryos, Mitf-expressing cells that coexpressed the melanoblast marker Dct and the tyrosine kinase receptor Kit were found in the...

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Identifiers

PMID: 9199364
DOI: 10.1242/dev.124.12.2377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor.PMID 9199364Read ↗

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Transcription factors in melanocyte development: distinct roles for Pax-3 and Mitf.Semantic proximity Read ↗

A late wave of melanoblast differentiation and rostrocaudal migration revealed in patch and rump-white embryos.Semantic proximity Read ↗

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Mitf contributes to melanosome distribution and melanophore dendricity.Semantic proximity Read ↗

Meningeal Melanocytes in the Mouse: Distribution and Dependence on MitfSemantic proximity Read ↗

MITF: a stream flowing for pigment cells.Semantic proximity Read ↗

The Role of the Microenvironment on the Localization of Hair and Skin Nonuniform Pigmented Spots in Mice with a Targeted Mutation in the Endothelin B Receptor.Semantic proximity Read ↗

Evidence to suggest that expression of MITF induces melanocyte differentiation and haploinsufficiency of MITF causes Waardenburg syndrome type 2A.Semantic proximity Read ↗

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