Article
The Dark brown plumage color in chickens is caused by an 8.3-kb deletion upstream of SOX10.
Pigment cell & melanoma research - 1 Apr 2011
Gunnarsson Ulrika, Kerje Susanne, Bed'hom Bertrand, Sahlqvist Anna-Stina, Ekwall Olov, Tixier-Boichard Michele, Kämpe Olle, Andersson Leif
Abstract excerpt
The Dark brown (DB) mutation in chickens reduces expression of black eumelanin and enhances expression of red pheomelanin, but only in certain parts of the plumage. Here, we present genetic evidence that an 8.3-kb deletion upstream of the SOX10 transcription start site is the causal mutation underlying the DB phenotype. The SOX10 transcription factor has a well-established role in melanocyte biology and is...
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