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Article

Structural and kinetic characterization of an acyl transferase ribozyme.

Journal of the American Chemical Society - 18 Feb 1998

Suga H, Lohse P A, Szostak J W

Abstract excerpt

We have previously isolated, by in vitro selection, an acyl-transferase ribozyme that is capable of transferring a biotinylated methionyl group from the 3' end of a hexanucleotide substrate to its own 5'-hydroxyl. Comparison of the sequences of a family of evolved derivatives of this ribozyme allowed us to generate a model of the secondary structure of the ribozyme. The predicted secondary structure was...

Topics

Acyltransferases
Base Composition
Base Sequence
Biotinylation
Directed Molecular Evolution
Models, Molecular
Molecular Structure
Mutation
Oligonucleotides
Polymerase Chain Reaction
RNA, Catalytic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis

Templates, Genetic

Source

Identifiers

PMID: 11541113
DOI: 10.1021/ja972472s

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