Article
Structural and kinetic characterization of an acyl transferase ribozyme.
Journal of the American Chemical Society - 18 Feb 1998
Suga H, Lohse P A, Szostak J W
Abstract excerpt
We have previously isolated, by in vitro selection, an acyl-transferase ribozyme that is capable of transferring a biotinylated methionyl group from the 3' end of a hexanucleotide substrate to its own 5'-hydroxyl. Comparison of the sequences of a family of evolved derivatives of this ribozyme allowed us to generate a model of the secondary structure of the ribozyme. The predicted secondary structure was...
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