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Article

Evolution in vitro: analysis of a lineage of ribozymes.

Current biology : CB - 1 Jan 1993

Lehman N, Joyce G F

Abstract excerpt

BACKGROUND: Catalytic RNAs, or ribozymes, possessing both a genotype and a phenotype, are ideal molecules for evolution experiments in vitro. A large, heterogeneous pool of RNAs can be subjected to multiple rounds of selection, amplification and mutation, leading to the development of variants that have some desired phenotype. Such experiments allow the investigator to correlate specific genetic changes with...

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PMID: 11539560
DOI: 10.1016/0960-9822(93)90019-k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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