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Article

The genotypic landscape during in vitro evolution of a catalytic RNA: implications for phenotypic buffering.

Journal of molecular evolution - 1 May 2000

Lehman N, Donne M D, West M, Dewey T G

Abstract excerpt

The Tetrahymena group I ribozyme catalyzes the cleavage of a phosphodiester linkage in specific sequences of RNA. This phenotype can be used in an in vitro selection-amplification process to evolve variants that are capable of RNA catalysis in the presence of Ca(2+) as the sole available cation. With sufficient genotypic characterization of the population as it evolves, we have a rare opportunity of observing how...

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Identifiers

PMID: 10824092
DOI: 10.1007/s002390010051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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