Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specialization of the DNA-cleaving activity of a group I ribozyme through in vitro evolution.

Journal of molecular biology - 13 Sept 1996

Tsang J, Joyce G F

Abstract excerpt

In an earlier study, an in vitro evolution procedure was applied to a large population of variants of the Tetrahymena group I ribozyme to obtain individuals with a 10(5)-fold improved ability to cleave a target single-stranded DNA substrate under simulated physiological conditions. The evolved ribozymes also showed a twofold improvement, compared to the wild-type, in their ability to cleave a single-stranded RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Evolution, Molecular
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutagenesis, Site-Directed

Share to Nucleic Acid Conformation

Share to Phenotype

Share to Substrate Specificity

Source

Identifiers

PMID: 8809177
DOI: 10.1006/jmbi.1996.0496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specialization of the DNA-cleaving activity of a group I ribozyme through in vitro evolution.PMID 8809177Read ↗

Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme.Semantic proximity Read ↗

Evolution in vitro: analysis of a lineage of ribozymes.Semantic proximity Read ↗

Directed evolution of an RNA enzyme.Semantic proximity Read ↗

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA.Semantic proximity Read ↗

Evolution of Tetrahymena ribozyme mutants with increased structural stability.Semantic proximity Read ↗

Replicability and recurrence in the experimental evolution of a group I ribozyme.Semantic proximity Read ↗

Experimental evolution of complexity: in vitro emergence of intermolecular ribozyme interactions.Semantic proximity Read ↗

In vitro genetic analysis of the Tetrahymena self-splicing intron.Semantic proximity Read ↗

Increased efficiency of evolved group I intron spliceozymes by decreased side product formation.Semantic proximity Read ↗

Evolution in vitro of an RNA enzyme with altered metal dependence.Semantic proximity Read ↗

In vitro evolution of a ribozyme that contains 5-bromouridine.Semantic proximity Read ↗

Elucidating Evolutionary Mechanisms and Variants of the Hammerhead Ribozyme Using In Vitro Selection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.