Article
Experimental evolution of complexity: in vitro emergence of intermolecular ribozyme interactions.
RNA (New York, N.Y.) - 1 Mar 1998
Hanczyc M M, Dorit R L
Abstract excerpt
In the course of evolving variants of the Tetrahymena thermophila Group I ribozyme for improved DNA cleavage in vitro, we witnessed the unexpected emergence of a derived molecular species, capable of acting as a partner for the ribozyme, but no longer autocatalytic. This new RNA species exhibits a deletion in the catalytic core and participates in a productive intermolecular interaction with an active ribozyme,...
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