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Article

Genomewide-linkage and haplotype-association studies map intracranial aneurysm to chromosome 7q11.

American journal of human genetics - 1 Oct 2001

Onda H, Kasuya H, Yoneyama T, Takakura K, Hori T, Takeda J, Nakajima T, Inoue I

Abstract excerpt

Rupture of intracranial aneurysms (IAs) causes subarachnoid hemorrhage, a devastating condition with high morbidity and mortality. Angiographic and autopsy studies show that IA is a common disorder, with a prevalence of 3%-6%. Although IA has a substantial genetic component, little attention has been given to the genetic determinants. We report here a genomewide linkage study of IA in 104 Japanese affected sib...

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Identifiers

PMID: 11536080
DOI: 10.1086/323614
PMCID: PMC1226066

Genes

ELN

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Related research

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Genomewide-linkage and haplotype-association studies map intracranial aneurysm to chromosome 7q11.PMID 11536080Read ↗

Confirmation of chromosome 7q11 locus for predisposition to intracranial aneurysm.Semantic proximity Read ↗

A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms.Semantic proximity Read ↗

Molecular genetic analysis of two large kindreds with intracranial aneurysms demonstrates linkage to 11q24-25 and 14q23-31.Semantic proximity Read ↗

Association analysis of common variants of ELN, NOS2A, APOE and ACE2 to intracranial aneurysm.Semantic proximity Read ↗

Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms.Semantic proximity Read ↗

Extended single nucleotide polymorphism and haplotype analysis of the elastin gene in Caucasians with intracranial aneurysms provides evidence for racially/ethnically based differences.Semantic proximity Read ↗

Genomewide linkage in a large Caucasian family maps a new locus for intracranial aneurysms to chromosome 13q.Semantic proximity Read ↗

Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23.Semantic proximity Read ↗

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