Article
Genomewide linkage in a large Caucasian family maps a new locus for intracranial aneurysms to chromosome 13q.
Stroke - 1 Mar 2009
Santiago-Sim Teresa, Depalma Steven R, Ju Kevin L, McDonough Barbara, Seidman Christine E, Seidman J G, Kim Dong H
Abstract excerpt
BACKGROUND AND PURPOSE: Familial aggregation of intracranial aneurysms (IAs) indicates a genetic role in the pathogenesis of this disease. Despite a number of reported susceptibility loci, no disease-causing gene variants have been identified. In this study, we used a parametric genomewide linkage approach to search for new IA susceptibility loci in a large Caucasian family. METHODS: The affection status of...
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