Article
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA.
Human molecular genetics - 1 May 2012
Low Siew-Kee, Takahashi Atsushi, Cha Pei-Chieng, Zembutsu Hitoshi, Kamatani Naoyuki, Kubo Michiaki, Nakamura Yusuke
Abstract excerpt
Aneurysmal subarachnoid hemorrhage (aSAH) is the most serious subtype of stroke. Genetic factors have been known to play an important role in the development of intracranial aneurysm (IA), some of which further progress to subarachnoid hemorrhage (SAH). In this study, we conducted a genome-wide a...
Topics
- Asian People
- Case-Control Studies
- Chromosomes, Human, Pair 4
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p15
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Intracranial Aneurysm
- Japan
- Polymorphism, Single Nucleotide
- Receptor, Endothelin A