Article
Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms.
Journal of human genetics - 1 Oct 2010
Akiyama Koichi, Narita Akira, Nakaoka Hirofumi, Cui Tailin, Takahashi Tomoko, Yasuno Katsuhito, Tajima Atsushi, Krischek Boris, Yamamoto Ken, Kasuya Hidetoshi, Hata Akira, Inoue Ituro
Abstract excerpt
An intracranial aneurysm (IA), which results in a subarachnoid hemorrhage with a high mortality on rupture, is a major public health concern. To identify genetic susceptibility loci for IA, we carried out a multistage association study using genome-wide single nucleotide polymorphisms (SNPs) in Japanese case-control subjects. In this study, we assessed evidence for association in standard approaches, and...
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