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Article

A Comparative Analysis of the Immunological Evolution of Antibody 28B4

15 Aug 2001

Abstract excerpt

In an effort to gain greater insight into the evolution of the redox active, catalytic antibody 28B4, the germline genes used by the mouse to generate this antibody were cloned and expressed, and the X-ray crystal structures of the unliganded and hapten-bound germline Fab of antibody 28B4 were determined. Comparison with the previously determined structures of the unliganded and hapten-bound affinity-matured Fab...

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PMID: 11535051
DOI: 10.1021/bi010536c

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