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Article

Structural plasticity and the evolution of antibody affinity and specificity.

Journal of molecular biology - 18 Jul 2003

Yin Jun, Beuscher Albert E, Andryski Scott E, Stevens Raymond C, Schultz Peter G

Abstract excerpt

The germline precursor to the ferrochelatase antibody 7G12 was found to bind the polyether jeffamine in addition to its cognate hapten N-methylmesoporphyrin. A comparison of the X-ray crystal structures of the ligand-free germline Fab and its complex with either hapten or jeffamine reveals that the germline antibody undergoes significant conformational changes upon the binding of these two structurally distinct...

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Source

Identifiers

PMID: 12850137
DOI: 10.1016/s0022-2836(03)00631-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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