Article
The immunological evolution of catalysis.
Science (New York, N.Y.) - 23 Feb 1996
Patten P A, Gray N S, Yang P L, Marks C B, Wedemayer G J, Boniface J J, Stevens R C, Schultz P G
Abstract excerpt
The germline genes used by the mouse to generate the esterolytic antibody 48G7 were cloned and expressed in an effort to increase our understanding of the detailed molecular mechanisms by which the immune system evolves catalytic function. The nine replacement mutations that were fixed during affinity maturation increased affinity for the transition state analogue by a factor of 10(4), primarily the result of a...
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