Article
The immunological evolution of catalysis.
Science (New York, N.Y.) - 23 Feb 1996
Patten P A, Gray N S, Yang P L, Marks C B, Wedemayer G J, Boniface J J, Stevens R C, Schultz P G
Abstract excerpt
The germline genes used by the mouse to generate the esterolytic antibody 48G7 were cloned and expressed in an effort to increase our understanding of the detailed molecular mechanisms by which the immune system evolves catalytic function. The nine replacement mutations that were fixed during aff...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Catalytic
- Antibody Affinity
- Antigen-Antibody Complex
- Antigen-Antibody Reactions
- Base Sequence
- Binding Sites
- Catalysis
- Cloning, Molecular
- Crystallization
- Crystallography, X-Ray
- Evolution, Molecular
- Genes, Immunoglobulin
- Haptens
- Immunoglobulin Fab Fragments
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains