Article
Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR.
Development (Cambridge, England) - 1 Aug 2001
Boyl P P, Signore M, Acampora D, Martinez-Barbera J P, Ilengo C, Annino A, Corte G, Simeone A
Abstract excerpt
Otx genes play an important role in brain development. Previous mouse models suggested that the untranslated regions (UTRs) of Otx2 mRNA may contain regulatory element(s) required for its post-transcriptional control in epiblast and neuroectoderm. In order to study this, we have perturbed the 3' UTR of Otx2 by inserting a small fragment of DNA from the lambda phage. Otx2(lambda) mutants exhibited proper...
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