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Regulation of Otx2 expression and its functions in mouse forebrain and midbrain.

Development (Cambridge, England) - 1 Jul 2004

Kurokawa Daisuke, Kiyonari Hiroshi, Nakayama Rika, Kimura-Yoshida Chiharu, Matsuo Isao, Aizawa Shinichi

Abstract excerpt

Otx2 expression in the forebrain and midbrain was found to be regulated by two distinct enhancers (FM and FM2) located at 75 kb 5' upstream and 115 kb 3' downstream. The activities of these two enhancers were absent in anterior neuroectoderm earlier than E8.0; however, at E9.5 their regions of activity spanned the entire mesencephalon and diencephalon with their caudal limits at the boundary with the...

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Conserved Sequence
Ectoderm
Enhancer Elements, Genetic
In Situ Hybridization
Mesencephalon

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Otx Transcription Factors

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PMID: 15201224
DOI: 10.1242/dev.01220

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Regulation of Otx2 expression and its functions in mouse forebrain and midbrain.PMID 15201224Read ↗

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