Mouse Otx2 functions in the formation and patterning of rostral head.

doi:10.1101/gad.9.21.2646

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Article

Mouse Otx2 functions in the formation and patterning of rostral head.

Genes & development - 1 Nov 1995

Matsuo I, Kuratani S, Kimura C, Takeda N, Aizawa S

Abstract excerpt

The anterior part of the vertebrate head expresses a group of homeo box genes in segmentally restricted patterns during embryogenesis. Among these, Otx2 expression covers the entire fore- and midbrains and takes place earliest. To examine its role in development of the rostral head, a mutation was introduced into this locus. The homozygous mutants did not develop structures anterior to rhombomere 3, indicating an...

Topics

Abnormalities, Multiple
Animals
Base Sequence
Ear
Embryo, Mammalian
Epithelium
Eye Abnormalities
Gene Expression Regulation, Developmental
Gestational Age
Haploidy
Head
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homeodomain Proteins

Homozygote

Jaw Abnormalities

Mice

Mice, Transgenic

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7590242
DOI: 10.1101/gad.9.21.2646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7590242-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mouse Otx2 functions in the formation and patterning of rostral head.PMID 7590242Read ↗

Functional equivalency between Otx2 and Otx1 in development of the rostral head.Semantic proximity Read ↗

Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain.Semantic proximity Read ↗

Deletion of OTX2 in neural ectoderm delays anterior pituitary development.Semantic proximity Read ↗

Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.Semantic proximity Read ↗

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.Semantic proximity Read ↗

Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.Semantic proximity Read ↗

The caudal limit of Otx2 expression positions the isthmic organizer.Semantic proximity Read ↗

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.Semantic proximity Read ↗

Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.Semantic proximity Read ↗

Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.Semantic proximity Read ↗

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