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Article

Mouse Otx2 functions in the formation and patterning of rostral head.

Genes & development - 1 Nov 1995

Matsuo I, Kuratani S, Kimura C, Takeda N, Aizawa S

Abstract excerpt

The anterior part of the vertebrate head expresses a group of homeo box genes in segmentally restricted patterns during embryogenesis. Among these, Otx2 expression covers the entire fore- and midbrains and takes place earliest. To examine its role in development of the rostral head, a mutation was introduced into this locus. The homozygous mutants did not develop structures anterior to rhombomere 3, indicating an...

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Identifiers

PMID: 7590242
DOI: 10.1101/gad.9.21.2646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mouse Otx2 functions in the formation and patterning of rostral head.PMID 7590242Read ↗

Functional equivalency between Otx2 and Otx1 in development of the rostral head.Semantic proximity Read ↗

Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain.Semantic proximity Read ↗

Deletion of OTX2 in neural ectoderm delays anterior pituitary development.Semantic proximity Read ↗

Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.Semantic proximity Read ↗

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.Semantic proximity Read ↗

Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.Semantic proximity Read ↗

The caudal limit of Otx2 expression positions the isthmic organizer.Semantic proximity Read ↗

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.Semantic proximity Read ↗

Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.Semantic proximity Read ↗

Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.Semantic proximity Read ↗

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