Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.

doi:10.1242/dev.125.24.5091

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Article

Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.

Development (Cambridge, England) - 1 Dec 1998

Acampora D, Avantaggiato V, Tuorto F, Briata P, Corte G, Simeone A

Abstract excerpt

Otx1 and Otx2, two murine homologs of the Drosophila orthodenticle (otd) gene, contribute to brain morphogenesis. In particular Otx1 null mice are viable and show spontaneous epileptic seizures and abnormalities affecting the dorsal telencephalic cortex. Otx2 null mice die early in development an...

Topics

Animals
Brain
Cell Line
DNA, Complementary
Embryonic and Fetal Development
Endoderm
Gastrula
Gene Expression Regulation, Developmental
Genotype
Homeodomain Proteins
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Hybridization

Mice

Mice, Knockout

Morphogenesis

Nerve Tissue Proteins

Otx Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 9811592
DOI: 10.1242/dev.125.24.5091

Genes

OTX1
OTX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9811592-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.PMID 9811592Read ↗

Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.Semantic proximity Read ↗

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.Semantic proximity Read ↗

OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain.Semantic proximity Read ↗

Otx genes in the development and evolution of the vertebrate brain.Semantic proximity Read ↗

Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.Semantic proximity Read ↗

The role of Otx and Otp genes in brain development.Semantic proximity Read ↗

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.Semantic proximity Read ↗

Functional equivalency between Otx2 and Otx1 in development of the rostral head.Semantic proximity Read ↗

Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo.Semantic proximity Read ↗

Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.Semantic proximity Read ↗

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