Article
OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation.
Development (Cambridge, England) - 1 Dec 2001
Acampora D, Boyl P P, Signore M, Martinez-Barbera J P, Ilengo C, Puelles E, Annino A, Reichert H, Corte G, Simeone A
Abstract excerpt
How gene activity is translated into phenotype and how it can modify morphogenetic pathways is of central importance when studying the evolution of regulatory control mechanisms. Previous studies in mouse have suggested that, despite the homeodomain-restricted homology, Drosophila orthodenticle (otd) and murine Otx1 genes share functional equivalence and that translation of Otx2 mRNA in epiblast and neuroectoderm...
Topics
- 3' Untranslated Regions
- 5' Untranslated Regions
- Active Transport, Cell Nucleus
- Animals
- Biological Evolution
- Body Patterning
- Brain
- Cytoplasm
- DNA, Complementary
- Drosophila