Article
Real-time PCR analysis of the N-acetyltransferase NAT1 allele *3, *4, *10, *11, *14 and *17 polymorphism in squamous cell cancer of head and neck.
Carcinogenesis - 1 Sept 2001
Fronhoffs S, Brüning T, Ortiz-Pallardo E, Bröde P, Koch B, Harth V, Sachinidis A, Bolt H M, Herberhold C, Vetter H, Ko Y
Abstract excerpt
Although tobacco smoke has been established as a main risk factor in the development of head and neck squamous cell cancer (HNSCC), genetic polymorphisms of xenobiotic metabolizing enzymes are supposed to modulate an individual's susceptibility to smoking-related HNSCC. N-acetyltransferase (NAT) 1 gene is known to be polymorphic and its protein product is implicated in the activation and detoxification of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
