Article
Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay.
Pharmacogenetics - 1 Jun 2000
Lo-Guidice J M, Allorge D, Chevalier D, Debuysère H, Fazio F, Lafitte L J, Broly F
Abstract excerpt
One major interest to analyse the extent of N-acetyltransferase 1 (NAT1*) allelic variation in the human population stems to a great extent from the possible association of interindividual differences in the metabolism of aromatic amines with certain chemically induced diseases, including cancer. Considering the increasing number of mutations in the NAT1 gene that are detected, NAT1* genotyping using conventional...
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