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Article

Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations.

Pharmacogenetics - 1 Feb 1998

Butcher N J, Ilett K F, Minchin R F

Abstract excerpt

Human N-acetyltransferase type 1 (NAT1) catalyses the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. Despite wide inter-individual variability in activity, historically, NAT1 was considered to be monomorphic in natu...

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Source

Identifiers

PMID: 9511183
DOI: 10.1097/00008571-199802000-00009

Genes

NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9511183-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations.PMID 9511183Read ↗

Genotyping human arylamine N-acetyltransferase type 1 (NAT1): the identification of two novel allelic variants.Semantic proximity Read ↗

Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1.Semantic proximity Read ↗

Human acetyltransferase polymorphisms.Semantic proximity Read ↗

Novel allele containing a 190C>T nonsynonymous substitution in the N-acetyltransferase (NAT2) gene.Semantic proximity Read ↗

Functional genomics of C190T single nucleotide polymorphism in human N-acetyltransferase 2.Semantic proximity Read ↗

Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus.Semantic proximity Read ↗

Identification of a novel allele at the human NAT1 acetyltransferase locus.Semantic proximity Read ↗

Polymorphism of human acetyltransferases.Semantic proximity Read ↗

Correlation between genotype and phenotype of the human arylamine N-acetyltransferase type 1 (NAT1).Semantic proximity Read ↗

Polymorphic NATs and cancer predisposition.Semantic proximity Read ↗

Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent.Semantic proximity Read ↗

Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.Semantic proximity Read ↗

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