Article
Ras mutations are rare in solitary cold and toxic thyroid nodules.
Clinical endocrinology - 1 Aug 2001
Krohn K, Reske A, Ackermann F, Müller A, Paschke R
Abstract excerpt
OBJECTIVE: Activation of ras proto-oncogenes as a result of point mutations is detectable in a significant percentage of most types of tumour. Similar to neoplasms of other organs, mutations of all three ras genes can be found in thyroid tumours. H-, K- and N-ras mutations have been detected in up to 20% of follicular adenomas and adenomatous nodules which were not functionally characterized. This raises the...
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