Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey.

European journal of endocrinology - 1 Oct 2006

Gozu Hulya Iliksu, Bircan Rifat, Krohn Knut, Müller Sandra, Vural Selahattin, Gezen Cem, Sargin Haluk, Yavuzer Dilek, Sargin Mehmet, Cirakoglu Beyazit, Paschke Ralf

Abstract excerpt

OBJECTIVE: Differences in iodine intake could account for the variable prevalences reported for somatic TSH receptor (TSHR) mutations in toxic thyroid nodules (TTNs). However, this question has not been settled, since no study has yet determined the TSHR mutation prevalence in regions with different iodine supplies in the same population using the same methodology. Therefore, we studied the prevalence of somatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Geography
Share to GTP-Binding Protein alpha Subunits, Gs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Iodine

Share to Polymorphism, Single-Stranded Conformational

Share to Prevalence

Share to Receptors, Thyrotropin

Share to Thyroid Nodule

Share to Turkey

Source

Identifiers

PMID: 16990652
DOI: 10.1530/eje.1.02253

Genes

TSHR
TTN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey.PMID 16990652Read ↗

High prevalence of TSHR/Gsα mutation-negative clonal hot thyroid nodules (HNs) in a Turkish cohort.Semantic proximity Read ↗

Detection of thyroid-stimulating hormone receptor and Gsalpha mutations: in 75 toxic thyroid nodules by denaturing gradient gel electrophoresis.Semantic proximity Read ↗

Autonomously functioning thyroid nodules in a former iodine-deficient area commonly harbor gain-of-function mutations in the thyrotropin signaling pathway.Semantic proximity Read ↗

Somatic mutations in thyroid nodular disease.Semantic proximity Read ↗

Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters.Semantic proximity Read ↗

Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.Semantic proximity Read ↗

[Mutations in the thyrotropin receptor gene in the pathogenesis of toxic thyroid adenomas, toxic goiter nodules and autosomal dominant hyperthyroidism].Semantic proximity Read ↗

Pathogenesis of toxic thyroid adenomas and nodules: relevance of activating mutations in the TSH-receptor and Gs-alpha gene, the possible role of iodine deficiency and secondary and TSH-independent molecular mechanisms.Semantic proximity Read ↗

Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.Semantic proximity Read ↗

Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan.Semantic proximity Read ↗

Somatic mutations in the thyrotropin receptor gene and not in the Gs alpha protein gene in 31 toxic thyroid nodules.Semantic proximity Read ↗

Two rare TSH receptor amino acid substitutions in toxic thyroid adenomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.