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Article

Autonomously functioning thyroid nodules in a former iodine-deficient area commonly harbor gain-of-function mutations in the thyrotropin signaling pathway.

European journal of endocrinology - 1 Oct 2003

Georgopoulos Neoklis A, Sykiotis Gerasimos P, Sgourou Argyro, Papachatzopoulou Adamantia, Markou Kostas B, Kyriazopoulou Venetsana, Papavassiliou Athanasios G, Vagenakis Apostolos G

Abstract excerpt

BACKGROUND: Somatic activating mutations of the thyrotropin (thyroid-stimulating hormone (TSH)) receptor (TSHR) and G(alphas) protein have been detected in solitary toxic adenomas and toxic multinodular goiters, but their role in the pathogenesis of autonomous nodules is debated. The frequency of mutations is highly variable among populations and is inversely proportional to iodine intake. DESIGN AND PATIENTS: We...

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Source

Identifiers

PMID: 14514342
DOI: 10.1530/eje.0.1490287

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Autonomously functioning thyroid nodules in a former iodine-deficient area commonly harbor gain-of-function mutations in the thyrotropin signaling pathway.PMID 14514342Read ↗

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