BRAF mutations are not an alternative explanation for the molecular etiology of ras-mutation negative cold thyroid nodules.

Abstract excerpt

Activation of the RAS/RAF/MEK/ERK/MAP kinase pathway is a known mediator of signaling that results in cellular proliferation. Moreover, this activation can lead to a growth advantage of tumor cells. Therefore, mitogenic mutations in the RAS family of oncogenes are detectable in a significant percentage in most tumors. Moreover, mutations in the BRAF gene have recently been suggested as an alternate predominant...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Exons
• Share to BRAF gene
• Share to Genes, ras