Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.

doi:10.1210/jcem.82.8.4144

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Article

Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.

The Journal of clinical endocrinology and metabolism - 1 Aug 1997

Parma J, Duprez L, Van Sande J, Hermans J, Rocmans P, Van Vliet G, Costagliola S, Rodien P, Dumont J E, Vassart G

Abstract excerpt

A total of 33 different autonomous hot nodules from 31 patients, originating mainly from Belgium, were investigated for the presence of somatic mutations in the TSH receptor and Gs alpha genes. This constitutes an extension of our previous study, including the first 11 nodules of the series. The...

Topics

Adenoma
Adult
Aged
Amino Acid Sequence
Animals
Base Sequence
Belgium
COS Cells
Cyclic AMP
DNA Mutational Analysis
Female
GTP-Binding Protein alpha Subunits, Gs
Gene Deletion
Humans
Inositol Phosphates

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Open in PubMed

Identifiers

PMID: 9253356
DOI: 10.1210/jcem.82.8.4144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9253356-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Male

Middle Aged

Mutation