Article
Detection of thyroid-stimulating hormone receptor and Gsalpha mutations: in 75 toxic thyroid nodules by denaturing gradient gel electrophoresis.
Journal of molecular medicine (Berlin, Germany) - 1 Jan 2001
Trülzsch B, Krohn K, Wonerow P, Chey S, Holzapfel H P, Ackermann F, Führer D, Paschke R
Abstract excerpt
The actual frequency of constitutively activating thyrotropin receptor or Gsalpha mutations in toxic thyroid nodules (TTNs) remains controversial as considerable variation in the prevalence of these mutations has been reported. We studied a series of 75 consecutive TTNs and performed mutation screening by the more sensitive method of denaturing gradient gel electrophoresis (DGGE) in addition to direct sequencing....
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