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Article

Prevalence of Ras mutations in thyroid neoplasia.

Clinical endocrinology - 1 Apr 1999

Esapa C T, Johnson S J, Kendall-Taylor P, Lennard T W, Harris P E

Abstract excerpt

OBJECTIVE: Mutations at codons 12, 13 or 61 of ras which result in constitutive activation occur frequently in human malignancies. There have been varied reports on their prevalence and hence their likely significance in the pathogenesis of primary thyroid neoplasia. To address this, we have examined a large series of benign and malignant thyroid tumours for ras mutations. DESIGN: Genomic DNA was analysed for the...

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Identifiers

PMID: 10468914
DOI: 10.1046/j.1365-2265.1999.00704.x

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