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Article

Clonal Origin of Toxic Thyroid Nodules with Constitutively Activating Thyrotropin Receptor Mutations

1 Jan 1998

Abstract excerpt

Constitutively activating TSH receptor mutations have recently been detected in toxic nodules. In vitro studies suggest that mutated receptor signaling constitutively elevates cAMP, which causes hyperfunction and proliferation of thyrocytes. Therefore, toxic nodules with constitutively activating somatic TSH receptor mutations should result from clonal expansion of a single mutated cell. To test this hypothesis,...

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Identifiers

PMID: 9435429
DOI: 10.1210/jcem.83.1.4477

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Clonal Origin of Toxic Thyroid Nodules with Constitutively Activating Thyrotropin Receptor MutationsPMID 9435429Read ↗

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Activating mutations of the TSH receptor gene cause thyroid diseases.Semantic proximity Read ↗

Hyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma.Semantic proximity Read ↗

Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.Semantic proximity Read ↗

Shared sporadic and somatic thyrotropin receptor mutations display more active in vitro activities than familial thyrotropin receptor mutations.Semantic proximity Read ↗

Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey.Semantic proximity Read ↗

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