Article
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
Science (New York, N.Y.) - 24 Aug 2001
Lewis J, Dickson D W, Lin W L, Chisholm L, Corral A, Jones G, Yen S H, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E
Abstract excerpt
JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice expressing mutant beta-amyloid precursor protein (APP), thus modulating the APP-Abeta (beta-amyloid peptide) environment. The resulting double mutant (tau/APP) progeny and the Tg2576 parental strain developed Abeta deposits at the same age;...
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