Article
Brain Abeta amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau.
The Journal of pathology - 1 Aug 2001
Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Shirao T, Ishiguro K, Okamoto K, Younkin S G, Shoji M
Abstract excerpt
APPsw transgenic mice (Tg2576) overproducing mutant amyloid beta protein precursor (betaAPP) show substantial brain Abeta amyloidosis and behavioural abnormalities. To clarify the subsequent abnormalities, the disappearance of neurons and synapses and dystrophic neurite formation with accumulated proteins including hyperphosphorylated tau were examined. Tg2576 demonstrated substantial giant core plaques and...
Topics
- Alzheimer Disease
- Amyloid Neuropathies
- Amyloid beta-Protein Precursor
- Animals
- Brain Diseases, Metabolic, Inborn
- Disease Models, Animal
- Membrane Proteins
- Mice
- Mice, Transgenic
- Mutation