Article
Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice.
Neurobiology of disease - 1 Dec 2005
Ribé Elena M, Pérez Mar, Puig Berta, Gich Ignasi, Lim Filip, Cuadrado Mar, Sesma Teresa, Catena Silvia, Sánchez Belén, Nieto María, Gómez-Ramos Pilar, Morán M Asunción, Cabodevilla Felipe, Samaranch Lluis, Ortiz Lourdes, Pérez Alberto, Ferrer Isidro, Avila Jesús, Gómez-Isla Teresa
Abstract excerpt
Even though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this type of dementia remains controversial. We further investigated the role of beta-amyloid production/deposition in tau pathology and neuronal cell death in the...
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