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Article

Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 May 2010

Clinton Lani K, Blurton-Jones Mathew, Myczek Kristoffer, Trojanowski John Q, LaFerla Frank M

Abstract excerpt

Alzheimer's disease (AD), the most prevalent age-related neurodegenerative disorder, is characterized pathologically by the accumulation of beta-amyloid (Abeta) plaques and tau-laden neurofibrillary tangles. Interestingly, up to 50% of AD cases exhibit a third prevalent neuropathology: the aggregation of alpha-synuclein into Lewy bodies. Importantly, the presence of Lewy body pathology in AD is associated with a...

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Identifiers

PMID: 20505094
DOI: 10.1523/JNEUROSCI.0490-10.2010
PMCID: PMC3308018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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