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Article

Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.

Neurobiology of disease - 1 Feb 2004

Boutajangout Allal, Authelet Michèle, Blanchard Véronique, Touchet N, Tremp Gunter, Pradier Laurent, Brion Jean-Pierre

Abstract excerpt

To study the role of Abeta amyloid deposits in the generation of cytoskeletal lesions, we have generated a transgenic mouse line coexpressing in the same neurons a wild-type human tau isoform (0N3R), a mutant form of APP (751SL) and a mutant form of PS1 (M146L). These mice developed early cerebral extracellular deposits of Abeta, starting at 2.5 months. A somatodendritic neuronal accumulation of transgenic tau...

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Source

Identifiers

PMID: 14751770
DOI: 10.1016/j.nbd.2003.09.007

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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