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Article

Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model.

Neurobiology of aging - 1 Jul 2017

Vanden Dries Virginie, Stygelbout Virginie, Pierrot Nathalie, Yilmaz Zehra, Suain Valérie, De Decker Robert, Buée Luc, Octave Jean-Noël, Brion Jean-Pierre, Leroy Karelle

Abstract excerpt

Alzheimer's disease is characterized by the presence of 2 neuropathological lesions: neurofibrillary tangles, composed of tau proteins which are highly phosphorylated and phosphorylated on uncommon sites, and amyloid plaques, containing the Aß peptides generated from the amyloid precursor protein (APP). Reduction of some APP proteolytic derivatives in Alzheimer's disease such as sAPPα fragment has been reported...

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Source

Identifiers

PMID: 28464981
DOI: 10.1016/j.neurobiolaging.2017.03.031

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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