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Article

Enhanced accumulation of phosphorylated alpha-synuclein in double transgenic mice expressing mutant beta-amyloid precursor protein and presenilin-1.

Journal of neuroscience research - 1 Aug 2007

Kurata Tomoko, Kawarabayashi Takeshi, Murakami Tetsuro, Miyazaki Kazunori, Morimoto Nobutoshi, Ohta Yasuyuki, Takehisa Yasushi, Nagai Makiko, Ikeda Masaki, Matsubara Etsuro, Westaway David, Hyslop Peter St George, Harigaya Yasuo, Kamiya Tatsushi, Shoji Mikio, Abe Koji

Abstract excerpt

A recent report showed that the accumulation of alpha-synuclein (alpha-syn) was detected in the brains of one-third of Alzheimer's disease and Down syndrome patients. However, the relationship between amyloid-beta protein (Abeta) and alpha-syn remains unclear. We analyzed the relation between the mutation of presenilin-1 (PS-1) and the pathological features of beta-amyloidosis and alpha-synucleinopathy. We...

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PMID: 17526016
DOI: 10.1002/jnr.21352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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