Article
Absence of hereditary mutations in exons 5 through 9 of the p53 gene and exon 24 of the neurofibromin gene in families with glioma.
Annals of neurology - 1 Jan 1994
van Meyel D J, Ramsay D A, Chambers A F, Macdonald D R, Cairncross J G
Abstract excerpt
Inherited mutations of the p53 and neurofibromin genes are thought to cause two distinct neoplastic disorders in which gliomas occur, the Li-Fraumeni syndrome and neurofibromatosis type 1. We investigated the possibility that inherited mutations in specific regions of these genes also contributed...
Topics
- Adult
- Base Sequence
- DNA, Neoplasm
- Exons
- Female
- Genes, Neurofibromatosis 1
- Genes, p53
- Glioma
- Humans
- Molecular Sequence Data
- Mutation
- Neurofibromin 1
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Proteins