Article
Opposite association of two PPARG variants with cancer: overrepresentation of H449H in endometrial carcinoma cases and underrepresentation of P12A in renal cell carcinoma cases.
Human genetics - 1 Aug 2001
Smith W M, Zhou X P, Kurose K, Gao X, Latif F, Kroll T, Sugano K, Cannistra S A, Clinton S K, Maher E R, Prior T W, Eng C
Abstract excerpt
Peroxisome proliferator activated receptor gamma (PPARgamma) is a nuclear hormone receptor that has been shown to regulate differentiation and cell growth. Studies of the differentiative effects of PPARgamma agonists on several cancer cell lines led to the hypothesis that dysfunction of PPARgamma contributes to tumorigenesis. These functional observations were strengthened by genetic evidence: somatic...
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