Article
Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.
eLife - 16 Nov 2017
Halstead Angela M, Kapadia Chiraag D, Bolzenius Jennifer, Chu Clarence E, Schriefer Andrew, Wartman Lukas D, Bowman Gregory R, Arora Vivek K
Abstract excerpt
RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs). Analysis from TCGA raised the possibility that hyperactive PPAR signaling, either due to PPAR gamma gene amplification or RXRA hot-spot mutation (S427F/Y) drives 20-25% of human bladder cancers. Here, we characterize mutant RXRA, demonstrating it induces...
Topics
- Allosteric Regulation
- Animals
- Cell Line
- Cell Proliferation
- Epithelial Cells
- Humans
- Mice
- Mutation
- Peroxisome Proliferator-Activated Receptors
- Retinoid X Receptor alpha