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Peroxisome proliferator-activated receptor (PPAR) gamma gene polymorphisms and colorectal cancer risk among Chinese in Singapore.

Carcinogenesis - 1 Sept 2006

Koh Woon-Puay, Yuan Jian-Min, Van Den Berg David, Ingles Sue A, Yu Mimi C

Abstract excerpt

Peroxisome proliferator-activated receptor (PPAR) gamma is a ligand-activated nuclear receptor that plays a key role in adipogenesis and adipocyte gene expression, and has recently been linked with possible antineoplastic effects in colonic carcinogenesis. PPARgamma2 and gamma3 are two transcripts arising from the PPARgamma gene through differential promoter usage and alternative splicing. We investigated the...

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PMID: 16513680
DOI: 10.1093/carcin/bgl001

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