Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell-Intrinsic Tumorigenic Functions of PPARγ in Bladder Urothelial Carcinoma.

Molecular cancer research : MCR - 1 Apr 2021

Sanchez Danielle J, Missiaen Rindert, Skuli Nicolas, Steger David J, Simon M Celeste

Abstract excerpt

The role of PPAR gamma (PPARγ) has been well characterized in the developmental process of adipogenesis, yet its aberrant expression patterns and functions in cancer subtypes are less understood. Although PPARγ has been recently demonstrated to play non-cell-autonomous roles in promoting bladder urothelial carcinoma (UC) progression, underlying mechanisms of the cell-intrinsic oncogenic activity remain unknown....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Carcinoma, Transitional Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Heterografts

Share to Mice, Nude

Share to PPAR gamma

Share to Pyridines

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 33431608
DOI: 10.1158/1541-7786.MCR-20-0189
PMCID: PMC8026526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell-Intrinsic Tumorigenic Functions of PPARγ in Bladder Urothelial Carcinoma.PMID 33431608Read ↗

Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer.Semantic proximity Read ↗

Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.Semantic proximity Read ↗

Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells.Semantic proximity Read ↗

Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-δ PathwaySemantic proximity Read ↗

Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancerSemantic proximity Read ↗

PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway.Semantic proximity Read ↗

The role of PPARγ in prostate cancer development and progressionSemantic proximity Read ↗

Retinoic acid receptor gamma is required for proliferation of pancreatic cancer cellsSemantic proximity Read ↗

PPARG in Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative IsoformsSemantic proximity Read ↗

Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancerSemantic proximity Read ↗

PPARγ is dispensable for clear cell renal cell carcinoma progressionSemantic proximity Read ↗

Loss of PPARγ Expression and Signaling Is a Key Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association With Tumor Stromal InflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.