Article
Mutational analysis of the peroxisome proliferator-activated receptor gamma gene in human malignancies.
Cancer research - 1 Jul 2001
Ikezoe T, Miller C W, Kawano S, Heaney A, Williamson E A, Hisatake J, Green E, Hofmann W, Taguchi H, Koeffler H P
Abstract excerpt
Peroxisome proliferator-activated receptor gamma (PPARgamma) plays an important role in adipocyte differentiation and is expressed in many human malignancies, including those from prostate, breast, as well as colon. It regulates differentiation and/or cell growth of these cells. However, expression of this nuclear hormone receptor in other types of cancer, especially in hematological malignancies, remains to be...
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